Opioids (narcotics) or morphine-like drugs (e.g. tramadol, suboxone) have been used for many years. It’s counter-intuitive to think that a drug like naltrexone, which blocks the effect of opioids, can help manage chronic pain. We do have some understanding that LDN (Low Dose Naltrexone) helps with autoimmune conditions. Current literatures in pain medicine supports the view that chronic pain, especially chronic nerve pain conditions such as Complex Regional Pain Syndrome (CRPS), Reflex Sympathetic Dystrophy (RSD), and Diabetic Peripheral Neuropathy (DPN) are autoimmune based. A study done on treating Fibromyalgia pain with LDN showed a 30% reduction in symptoms. Below is a short description of the mechanism behind chronic nerve pain.